The Los Angeles Memorial Coliseum hosted USC Springfest, the university’s annual student‑only spring music festival. The 2025 lineup featured multiple emerging and chart‑rising artists, with Don Toliver headlining and delivering a high‑intensity set that included hits like Lemonade, After Party, and CAN’T SAY, alongside several reprises and a new unreleased track. Additional performers included Lyn Lapid, Michele Lu, thebandfriday, and Small Talk, representing a mix of pop, indie, hip‑hop, and electronic styles. The festival continued USC’s tradition of showcasing major national artists in a campus‑community setting, marking another memorable cultural moment in the Coliseum’s modern entertainment history.

USC Football played its inaugural Big Ten Conference home game at the Los Angeles Memorial Coliseum, hosting the Wisconsin Badgers in a historic milestone for the program. Historically, USC Football has competed across multiple conference eras. The program was an early member of the Pacific Coast Conference (PCC) from 1922 until its dissolution in 1959. Following that, USC became a founding member of the Pac-8 Conference, which later expanded and evolved into the Pac-10 Conference and ultimately the Pac-12 Conference—a conference USC called home for over six decades and where it built its national powerhouse identity. In 2024, USC officially transitioned to the Big Ten Conference, marking a new chapter defined by cross-country competition, expanded media reach, and a redefined national footprint. Moreover, the win symbolized USC’s competitive arrival in its new conference era and highlighted the Coliseum’s continued role as a stage for major program milestones.

USC and Notre Dame have long been rivals, drawing thousands of extra fans to the crowd. While every time USC plays Notre Dame is of note, the rivalry game that took place on November 30, 1974 was unlike any other. Sports Illustrated called the game the “17 minutes that shook LA.”

As the game started, it didn’t appear to be an immediate Trojan win. Notre Dame's score went as high as 24-0, with the Trojans yet to score any points. Notre Dame’s line calls were perfectly aligned, while USC was throwing short passes. Notre Dame had a strong first half, led by Clements and Bullock. Trojan fans were losing hope while Notre Dame fans cheered and screamed through the Coliseum.

As soon as the clock started for the second half of the game, the tables turned when Anthony Davis took the second-half opening kick back 102 yards. Five Notre Dame turnovers came next, and soon the USC Trojans had scored 55 points in a matter of 17 minutes. Notre Dame did not score once the entire second half. To this day, the third quarter of “The Comeback” game is the most points ever scored on Notre Dame in a single quarter — a day that went down in history for the fans and players of USC football.

Several months after the Los Angeles Memorial Coliseum opened its doors to the Los Angeles community, over 20,000 fans swarmed through the entrance to watch the Coliseum’s first ever football game: USC vs. Pomona-Pitzer. The game was a doubleheader, opened by USC’s Freshmen team, known as the “Peagreeners,” playing Santa Ana High School. Next up, the Trojans swept the field against Pomona in a 23-7 win, guided by Coach Henderson. USC showed the crowd they were perfectly at home in their shiny new bowl, equipped with all the comforts and amenities of what was coined the “Greatest Stadium in the World.”

The game was carried by USC’s Dolley and Campbell, who were running through Pomona’s defense until they were dizzy. By halftime, the score was USC 17; Pomona 0. In the second half, Pomona scored their sole touchdown. This was USC’s first of hundreds of wins in the Los Angeles Memorial Coliseum, and the first fans of millions to watch football in the stadium.

Back on January 1, 1923, USC played Penn State in the 9th Rose Bowl, winning with a final score of 14-3.